Functional Proteomics Analysis to Study ATM Dependent Signaling in Response to Ionizing Radiation
نویسندگان
چکیده
منابع مشابه
Cellular response to ionizing radiation: A microRNA story
MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. Recently it has been discovered that mi...
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In mammals, the ATM (ataxia-telangiectasia-mutated) and ATR (ATM and Rad3-related) protein kinases function as critical regulators of the cellular DNA damage response. The checkpoint functions of ATR and ATM are mediated, in part, by a pair of checkpoint effector kinases termed Chk1 and Chk2. In mammalian cells, evidence has been presented that Chk1 is devoted to the ATR signaling pathway and i...
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ژورنال
عنوان ژورنال: Radiation Research
سال: 2013
ISSN: 0033-7587
DOI: 10.1667/rr3198.1